Spy trial us

Study Description. The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.

Detailed Description:. Information about agents disposition will be as follows: Every trial participant will have blood collected at trial enrollment, day 3, and day 7 for pre-specified biomarker and DNA and RNA analysis. FDA Resources. Arms and Interventions. Participants who receive remdesivir as part of their standard of care will be administered remdesivir by IV for up to ten days.

Nebulized aerosol medication that is inhaled recombinant DNAse. Treatment course is 14 days total return to room air or baseline oxygen use for 24hours, or until hospital discharge, whichever comes first.

For high-flow nasal cannula HFNC 2. Monoclonal antibody that blocks CD14, a cell surface and soluble protein that acts as a cofactor in triggering innate immune inflammation to pathogen- and damage-associated molecular patterns.

Histamine-2 H2 receptor antagonist and inverse agonist acts via a well-documented mechanism of action involving histamine H2 receptor blockade as well as interference with mast cell autocrine amplification of activation and degranulation which may reduce the proinflammatory response. If weekend narsoplimab administration is not feasible, administration day can be worked around as long as the intervals do not exceed days.

If weekend narsoplimab administration is not feasible, administration day can be worked around aslong as the intervals do not exceed days. Drug should be administered q8H, for a maximum of 14 days maximum 42 doses. Drug solution is provided in a syringe for convenient filling of nebulizer and should be used neat undiluted.

Outcome Measures. Total grade 3 or higher AEs by arm and total number of patients with grade 3 or higher AEs by arm. Eligibility Criteria. Inclusion Criteria: A.

Male or Female, at least 18 years old. Exclusion Criteria: A. Pregnant or breastfeeding women. Comfort measures only. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. Ramos med. Martinez hoag. Bayne uphs. Lutz SanfordHealth. More Information.

Publications automatically indexed to this study by ClinicalTrials. Cochrane Database Syst Rev. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Phase 2. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Platform Trial, Bayesian Design, from 5 arms up to 8 arms. Actual Study Start Date :. Estimated Primary Completion Date :.

The case has strained ties between Moscow and Washington and fuelled speculation of a prisoner swap. Whelan, 50, has been held in a Moscow jail since his arrest in December and his trial was held behind closed doors because of the accusations of seeking to obtain state secrets. He had complained of being mistreated in prison and last month underwent an urgent hernia operation at a Moscow hospital. Whelan's conviction is another impediment in relations between the two world powers, which are at odds over Ukraine, Syria, Libya, arms control and a host of other issues.

He said the United States was outraged "after a secret trial, with secret evidence, and without appropriate allowances for defence witnesses". The US ambassador to Moscow John Sullivan condemned the trial as unfair and lacking transparency, saying he was "disappointed, outraged" by the verdict. He said Whelan was "sentenced to 16 years in prison with no evidence that's been produced. Kremlin spokesman Dmitry Peskov dismissed allegations Whelan's detention was political saying: "The charges brought against him were proven in court and accepted by the court.

Throughout the hearings, Whelan insisted he was innocent, saying he was framed and comparing himself to the hapless comedy character Mr Bean. Whelan says he was detained on a visit to Moscow to attend a wedding when he took a USB drive from an acquaintance thinking it contained holiday photographs.

Whelan, who also has British, Canadian and Irish passports, was sentenced to 16 years in a strict regime penal colony. The prosecutor said last month Whelan tried to receive information that was a state secret and could harm Russia's security, Whelan's lawyer Vladimir Zherebenkov told reporters. The prosecutor claimed Whelan has the rank of an officer -- "at least a colonel" -- at the US defence intelligence agency, the lawyer said. Whelan was dishonourably discharged as a marine before working as head of global security at a US auto parts company.

Whelan's lawyer said Monday that Russian intelligence services were considering an exchange for two Russians detained in the United States, including pilot Konstantin Yaroshenko, imprisoned on drug smuggling charges. David Whelan has said that the family hoped a conviction would allow Russia and the United States to begin discussing Paul's release immediately. US diplomats and the former marine's family have condemned Whelan's treatment in detention, saying Russia ignored his medical condition and barred him from communicating with relatives.

President Joe Biden barely had time to shake off Sen. Kyrsten Sinema's body slam Thursday when the U.

Supreme Court knocked him down again. Two Crimson Tide coaches are accepting promotions at there big-time programs. Kate Middleton had a private video call with Meghan Markle and Prince Harry on her 40th birthday and a source is spilling details. Close this content. Read full article. Story continues.

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